Back when Twitter was just T-w-t-t-r, Josh Kopelman decided against investing in the microblogging startup.
“That is my most spectacular failure,” the First Round Capital founder said at a San Francisco tech conference on Thursday, the same day Twitter announced that it had filed plans to go public.
Read the Wall Street Journal’s account of Kopelman’s Twitter story here.
In a year defined by industrial policy, AI infrastructure and a still-surging entrepreneurship boom, one US region used 2025 especially well.
The org’s accelerators are ending, but its for-profit spinoff will still offer networking and matching without disruption, leaders say.
The federal SBIR grant will support upgrading the Pittsburgh space startup’s Xodiac and Xogdor vehicles.
From logistics to software to biotech, founders across the region are tackling healthcare’s hardest problems by focusing on real workflows, long timelines and patient impact.
Plus, the Science Center announced its ninth Capital Readiness cohort, meet the winners of Hopeworks’ young entrepreneurs pitch competition and more power moves.
Partnerships with giants like Eli Lilly and Thermo Fisher Scientific put biotech in the spotlight again, though founders still struggle to find investments in their hometown.
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