Life sciences / Real estate / Startups / STEM

One uCity Square is officially open, housing life science companies and research labs

The building is part of the larger uCity Square development project and is already home to commercial tenants including Century Therapeutics, Exponent and Integral Molecular.

One uCity Square. (Photo courtesy of Wexford Science & Technology)

University City introduced its newest shiny building last week when the One uCity Square building officially opened with a ribbon cutting on Thursday.

The 400,000-square-foot space at 37th and Cuthbert streets will house research labs and life sciences companies. This includes Penn Medicine’s Institute for RNA Innovation and Penn Engineering’s Center for Precision Engineering in Health.

Local life sciences companies Century Therapeutics, Exponent and Integral Molecular are among the commercial tenants that already call the building home. Integral Molecular, a life sciences research and development company, opened its offices and lab space at One uCity Square this spring.

Integral Molecular lab. (Courtesy photo)

“uCity Square is more than just lab and office space; it also represents a dynamic cluster of talent, innovation, collaboration, and opportunity that helps our recruiting, research, partnerships, and productivity,” said Sharon Willis, cofounder of Integral Molecular, in a written statement.

The building is 13 stories tall with both lab and office spaces, outdoor terraces, and onsite parking for cars and bikes. The first floor has retail and meeting space.

Developer Wexford Science and Technology partnered with Ventas Inc. and the University City Science Center on this building, which is part of a larger, years-long project to develop uCity Square.

This includes The Square, a public outdoor space across from One uCity Square that plans to host community events for the surrounding neighborhood. The development partners plan to add 4 million more square feet of space to the larger uCity Square project.

Ribbon cutting at One uCity Square. (Courtesy photo)

“The University of Pennsylvania’s decision to position key research labs in One uCity Square paired with the momentum with which high growth companies choose to locate in the building is further validation of the importance of the uCity Square Knowledge Community as an inclusive hub of university research, corporate engagement, start-up activity, community programming, and quality-of-life amenities,” said John Grady, SVP and northeast region executive for Wexford.

Sarah Huffman is a 2022-2024 corps member for Report for America, an initiative of The Groundtruth Project that pairs young journalists with local newsrooms. This position is supported by the Lenfest Institute for Journalism.
Companies: Integral Molecular / University City Science Center / University of Pennsylvania

Before you go...

Please consider supporting to keep our independent journalism strong. Unlike most business-focused media outlets, we don’t have a paywall. Instead, we count on your personal and organizational support.

3 ways to support our work:
  • Contribute to the Journalism Fund. Charitable giving ensures our information remains free and accessible for residents to discover workforce programs and entrepreneurship pathways. This includes philanthropic grants and individual tax-deductible donations from readers like you.
  • Use our Preferred Partners. Our directory of vetted providers offers high-quality recommendations for services our readers need, and each referral supports our journalism.
  • Use our services. If you need entrepreneurs and tech leaders to buy your services, are seeking technologists to hire or want more professionals to know about your ecosystem, has the biggest and most engaged audience in the mid-Atlantic. We help companies tell their stories and answer big questions to meet and serve our community.
The journalism fund Preferred partners Our services

Join our growing Slack community

Join 5,000 tech professionals and entrepreneurs in our community Slack today!


9 don't-miss events for technologists and entrepreneurs this July

Philadelphia Police are investigating vandalism at the home of a Ghost Robotics exec and the company’s Penn HQ

Top 3 vital trends founders should know before pitching investors in 2024

An OpenAI advisor wants to help tech leaders embrace the humanities

Technically Media