AgeneBio gets grants to advance therapeutics to slow Alzheimer's disease - Technical.ly Baltimore

Sciences

Oct. 11, 2018 6:59 pm

AgeneBio gets grants to advance therapeutics to slow Alzheimer’s disease

The NIH grants for an expected $16 million will help the company with Phase 3 trials.
AgeneBio CEO Michela Gallagher.

AgeneBio CEO Michela Gallagher.

(Courtesy photo)

Baltimore-based AgeneBio announced a pair of grants from the National Institutes of Health that will assist with clinical trials of a treatment to combat the progression of Alzheimer’s disease.

The awards from the NIH’s National Institute of Aging and the National Institute of Neurological Disorders and Stroke are expected to provide $16 million in funding, the company states.

The company’s work is based on the research of Dr. Michela Gallagher, who heads the Neurogenetics and Behavior Center at Johns Hopkins University and is currently serving as CEO of the company while on leave from the university. The research shows that overactivity in the hippocampus contributes to cognitive impairment. AgeneBio is developing treatments to slow Mild Cognitive Impairment due to Alzheimer’s disease. The condition causes a noticeable decline in cognitive abilities including memory, according to the Alzheimer’s Association.

According to the Mt. Washington–based company, the grants fund a Phase III clinical trial of a therapeutic to treat the condition. Dubbed the “Hope4MCI” trial, it will include a sub-study that includes imaging tools developed by Cerveau Technologies and Johns Hopkins Center for Imaging Science to track how the disease effects the brain, and the potential to slow it down.

Phase 3 trials typically precede an application to the FDA for approval to market a product.

“Previous support by NIA has already enabled us to complete study start up activities for the HOPE4MCI trial,” Sharon Rosenzweig-Lipson, AgeneBio’s Vice President of Research and Development, said in a statement. “The new grant will allow us to rapidly begin enrollment in the trial putting us one step closer to understanding the impact of hippocampal overactivity and tau pathology in this disease and to being able to treat MCI due to AD.”

Dr. Gallagher was also recently awarded the 2018 Melvin R. Goodes Prize for Excellence in Alzheimer’s Drug Discovery by the Alzheimer’s Drug Discovery Foundation, which came with a $150,000 award that is being used toward the Phase 3 trial, according to a news release.

Advertisement

Another grant is supporting a separate therapeutic that is designed to normalize brain functions in the early stages of Alzheimer’s.

-30-
CONTRIBUTE TO THE
JOURNALISM FUND

Already a contributor? Sign in here
Connect with companies from the Technical.ly community
New call-to-action

Advertisement

Between Two Founders: Talking money education with Ortus Academy

Microsoft is throwing support behind these Hopkins AI and data science startups

These 9 startups just finished Conscious Venture Lab. Here’s how they want to create impact *and* value

SPONSORED

Baltimore

Technology is ever evolving — shouldn’t business education be, too?

Baltimore, MD

SmartLogic

Developer

Apply Now

Philadelphia

Urban Outfitters

Urban Outfitters: Jr. Motion Graphic Designer

Apply Now

Philadelphia

URBN

URBN: User Experience (UX) Designer

Apply Now

Cashflow and confidence: Startup Portal opens space to work with entrepreneurs in Westminster

Chesapeake Digital Health Exchange aims to spur regional startup growth

5 ways to plug into Baltimore’s tech and biz resources to kick off 2020

SPONSORED

Baltimore

How independence fuels confidence and professional development at SmartLogic

Baltimore

14 West

F5 Engineer

Apply Now

Hunt Valley, MD

LawIQ

SOFTWARE ENGINEER – FULL TIME OPPORTUNITY

Apply Now

Annapolis Junction, MD

Asymmetrik

SOFTWARE ENGINEER

Apply Now

Sign-up for daily news updates from Technical.ly Baltimore

Do NOT follow this link or you will be banned from the site!